Endocrine Abstracts

Graves’ orbitopathy (GO) is a serious, progressive eye condition seen in patients with autoimmune thyroid disease. GO is characterized by inflammation and swelling of soft orbital tissues. Adipose tissue produces cytokine mediators called adipokines. The present study focuses on the relationship between serum levels of selected adipokines in patients with GO, comparing them with the control group, and uniquely describes the effect of high-dose systemic corticosteroids (HD...

Differential diagnostic search for the pathogenetic causes of hirsutism and the combination of hypertension can provide very interesting results for the clinicians. The case report demonstrates a patient suffering from two hormonally active tumors – adrenal adenoma with primary aldosteronism and primary Leydig cell ovarian tumor with hyperandrogenism. The task of the authors was easier due to the perimenopausal age of the proband. Selective venous sampling was very helpfu...

Introduction: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP9) and allograft inflammatory factor-1 (AIF-1) belong to the proteins produced by adipocyte tissue, which differently contribute to oxidative stress, chronic inflammation, insulin resistance and endothelial damage. The aim of this pilot study was to compare their levels in patients with diabetes and in healthy individuals and determine ...

Introduction: The aim of this study was to evaluate the plasma levels of adiponectin and tumor necrosis factor-alpha (TNF-α) in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these cytokines and selected risk factors for atherosclerosis, markers of insulin resistance and inflammation.Methods: Eighty-two members of 29 FCH families were divided into two groups: HL (prob...